The Blues were knocked out at this stage last season when they were beaten by Radcliffe Boro but gained their revenge this year beating them 5-1 in the quarter-final stage.
Charnock Richard on the other hand saw off Padiham beating them 3-1 in the last round.
Simon Haworth boasts a full strength side for the game with midfielder Ross Dent back from Suspension.
Charnock Richard are enjoying a very good season and are sat 3rd in the North West Counties league table so they will be no pushovers.
The Blues on the other hand are in the middle of a bad spell in the league and have fallen out of the top six after Saturday's 0-1 loss to South Shields.
There is a lot up for grabs with the winners given the chance to play at Bolton's Macron Stadium in the final.
We hope you can make the trip to Leyland on Wednesday and support the Blues!
Updated 10:00 - 24 Feb 2018 by Michael Barker